Dane R. Van Domelen

Website | GitHub page

Address:
85 Wells Ave., 2nd floor
Newton, MA 02459

Contact:

(Last updated Aug. 26, 2022)

Education


2018: PhD in Biostatistics, Emory University

2016: MS in Biostatistics, Emory University

2009: BS in Biomedical Engineering, Milwaukee School of Engineering


Work


Karyopharm Therapeutics Inc., Newton, MA

July 2022-Present: Principal Biostatistician

July 2020-June 2022: Senior Biostatistician

July 2019-June 2020: Biostatistician


Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

Aug. 2018-June 2019: Postdoctoral Fellow in Biostatistics


Awards


2018-2019: Epidemiology and Biostatistics of Aging Training Grant (NIA-T32)

2013-2018: National Science Foundation Graduate Research Fellowship

2012-2017: George W. Woodruff Fellowship


Publications

Methodological

Van Domelen, D.R. & Lyles, R.H. (2020). Formulas and web app for designing a pooling study to compare group means. Epidemiology, 31(1): 98-102. doi: 10.1097/EDE.0000000000001104.

Van Domelen, D.R. & Bandeen-Roche, K. (2019). A note on proposed estimation procedures for claims-based frailty indexes. American Journal of Epidemiology, 189(5): 369-371. doi: 10.1093/aje/kwz247.

Van Domelen, D.R., Mitchell, E.M., Perkins, N.J., Schisterman, E.F., Manatunga, A.K., Huang, Y., & Lyles, R.H. (2019). Gamma models for estimating the odds ratio for a skewed biomarker measured in pools and subject to errors. Biostatistics. doi: 10.1093/biostatistics/kxz028.

Van Domelen, D.R. & Lyles, R.H. (2019). A look at propensity score calibration’s unique identifiability. American Journal of Epidemiology, 188 (7): 1397–1399. doi: 10.1093/aje/kwz072.

Van Domelen, D.R., Mitchell, E.M., Perkins, N.J., Schisterman, E.F., Manatunga, A.K., Huang, Y., & Lyles, R.H. (2018). Logistic regression with a continuous exposure measured in pools and subject to errors. Statistics in Medicine, 37(27): 4007-4021. doi: 10.1002/sim.7891.

Lyles, R.H., Van Domelen, D.R., Mitchell, E.M., & Schisterman, E.F. (2015). A discriminant function approach to adjust for processing and measurement error when a biomarker is assayed in pooled samples. International Journal of Environmental Research and Public Health, 12(11): 14723-14740. doi: 10.3390/ijerph121114723.

Applied

Gounder, M.M., Razak, A.A., Somaiah, N., Chawla, S., Martin-Broto, J., Grignani, G., Schuetze, S.M., Vincenzi, B., Wagner, A.J., Chmielowski, B., Jones, R.L., Riedel, R.F., Stacchiotti, S., Loggers, E.T., Ganjoo, K.N., Le Cesne, A., Italiano, A., Garcia Del Muro, X., Burgess, M., Piperno-Neumann, S., Ryan, C., Mulcahy, M.F., Forscher, C., Penel, N., Okuno, S., Elias, A., Hartner, L., Philip, T., Alcindor, T., Kasper, B., Reichardt, P., Lapeire, L., Blay, J.Y., Chevreau, C., Valverde Morales, C.M., Schwartz, G.K., Chen, J.L., Deshpande, H., Davis, E.J., Nicholas, G., Gröschel, S., Hatcher, H., Duffaud, F., Herráez, A.C., Beveridge, R.D., Badalamenti, G., Eriksson, M., Meyer, C., von Mehren, M., Van Tine, B.A., Götze, K., Mazzeo, F., Yakobson, A., Zick, A., Lee, A., Gonzalez, A.E., Napolitano, A., Dickson, M.A., Michel, D., Meng, C., Li, L., Liu, J., Ben-Shahar, O., Van Domelen, D.R., Walker, C.J., Chang, H., Landesman, Y., Shah, J.J., Shacham, S., Kauffman, M.G., Attia, & S. Selinexor in advanced, metastatic dedifferentiated liposarcoma: a multinational, randomized, double-blind, placebo-controlled trial. Journal of Clinical Oncology, 40(22): 2479-2490. doi: 10.1200/JCO.21.01829.

Gasparetto, C., Schiller, G.J., Tuchman, S.A., Callander, N.S., Baljevic, M., Lentzsch, S., Rossi, A.C., Kotb, R., White, D., Bahlis, N.J., Chen, C.I., Sutherland, H.J., Madan, S., LeBlanc, R., Sebag, M., Venner, C.P., Bensinger, W.I., Biran, N., Ammu, S., Ben-Shahar, O., DeCastro, A., Van Domelen, D., Zhou, T., Zhang, C., Bentur, O.S., Shah, J., Shacham, S., Kauffman, M., & Lipe, B. (2021). Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients. British Journal of Cancer. doi: 10.1038/s41416-021-01608-2.

Gasparetto, C., Lentzsch, S., Schiller, G., Callander, N., Tuchman, S., Chen, C., White, D., Kotb, R., Sutherland, H., Sebag, M., Baljevic, M., Bensinger, W., LeBlanc, R., Venner, C., Bahlis, N., Rossi, A., Biran, N., Sheehan, H., Saint-Martin, J.R., Van Domelen, D., Kai, K., Shah, J., Shacham, S., Kauffman, M. & Lipe, B. (2021). Selinexor, daratumumab, and dexamethasone in patients with relapsed or refractory multiple myeloma. eJHaem, 2(1): 56-65. doi: 10.1002/jha2.122.

Steeves, J.A., Shiroma, E.J., Conger, S.A., Van Domelen, D.R., & Harris, T.B. (2019). Physical activity patterns and multimorbidity burden of older adults with different levels of functional status. Disability and Health Journal, 12(3): 495-502. doi: 10.1016/j.dhjo.2019.02.005.

van der Berg, J.D., Stehouwer, C.D.A., Bosma, H., Caserotti, P., Eiriksdottir, G., Arnardottir, N.Y., Van Domelen, D.R., Brychta, R.J., Chen, K.Y., Sveinsson, T., Johannsson, E., Launer, L.J., Gudnason, V., Jonsson, P.V., Harris, T.B., & Koster, A. (2019). Dynamic sitting: Measurement and associations with metabolic health. Journal of Sports Sciences, 36(17): 1-9. doi: 10.1080/02640414.2019.1592800.

Steeves, J.A., Tudor-Locke, C., Murphy R.A., King G.A., Fitzhugh, E.C., Bassett, D.R., Van Domelen, D.R., Schuna, J.M., & Harris, T.B. (2018). Daily physical activity by occupational classification in US adults: NHANES 2005-2006. Journal of Physical Activity and Health, 15(12): 900-911. doi: 10.1123/jpah.2017-0465.

Van Domelen, D.R. (2018). Frequent activity and minimal sedentary time throughout the day: an impractical goal with unproven benefits. Letter to editor. Journal of Physiology, 596(8): 1527. doi: 10.1113/JP275108.

Arnardottir, N.Y., Oskarsdottir, N.D., Brychta, R.J., Koster, A., Van Domelen, D.R., Caserotti, P., Eiriksdottir, G., Sverrisdottir, J.E., Johannsson, E., Launer, L.J., Gudnason, V., Harris, T.B., Chen, K.Y., & Svensson, T. (2017). Comparison of summer and winter objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility Reykjavik Study. International Journal of Environmental Research and Public Health, 14(10): 1268. doi: 10.3390/ijerph14101268.

Matthews, C.E., Keadle, S.K., Troiano, R.P., Kahle, L., Koster, A., Brychta, R.J., Van Domelen, D.R., Caserotti, P., Chen, K.Y., Harris, T.B., & Berrigan, D. (2016). Accelerometer-measured dose-response for physical activity, sedentary time, and mortality in US adults. American Journal of Clinical Nutrition, 104(5): 1424-1432. doi: 10.3945/ajcn.116.135129.

Kwak, L., Berrigan, D., Van Domelen, D.R., Sjostrom, M., & Hagstromer, M. (2016). Examining differences in physical activity levels by employment status and/or job activity level: Gender-specific comparisons between the United States and Sweden. Journal of Science and Medicine in Sport, 19(6): 482-7. doi: 10.1016/j.jsams.2015.05.008.

Arnardottir, N.Y., Koster, A., Van Domelen, D.R., Brychta, R.J., Caserotti, P., Eiriksdottir, G., Sverrisdottir, J.E., Sigurdsson, S., Johannsson, E., Chen, K.Y., Gudnason, V., Harris, T.B., Launer, L.J., & Sveinsson, T. (2015). Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study. Behavioural Brain Research, 296: 118-24. doi: 10.1016/j.bbr.2015.09.005.

Van Domelen, D.R. (2015). Part-time work and physical activity in American high school students. Journal of Occupational and Environmental Medicine, 57(8): 904-9. doi: 10.1097/JOM.0000000000000497.

Steeves, J.A., Murphy, R.A., Crainiceanu, C.M., Zipunnikov, V., Van Domelen, D.R., & Harris, T.B. (2015). Daily patterns of physical activity by type 2 diabetes definition: Comparing diabetes, prediabetes, and participants with normal glucose levels in NHANES 2003-2006. Preventive Medicine Reports, 2: 152-7. doi: 10.1016/j.pmedr.2015.02.007.

Martin, K.R., Koster, A., Murphy, R.A., Van Domelen, D.R., Hung, M., Brychta, R.J., Chen, K.Y., & Harris, T.B. (2015). Changes in daily activity patterns with age among US men and women: NHANES 2003-04 and 2005-06. Journal of the American Geriatrics Society, 62(7): 1263-71. doi: 10.1111/jgs.12893.

Van Domelen, D.R. & Pittard, W.S. (2014). Flexible R functions for processing accelerometer data, with emphasis on NHANES 2003-2006. The R Journal, 6(2): 52-62. Article.

Hunt, M.O., Weissfeld, L., Boudreau, R.M., Aizenstein, H., Newman, A.B., Simonsick, E.M., Van Domelen, D.R., Thomas, F., Yaffe, K., & Rosana, C. (2014). A variant of sparse partial least squares for variable selection and data exploration. Frontiers in Neuroinformatics, 8(18). doi: 10.3389/fninf.2014.00018.

Dansie, E.J., Turk, D.C., Martin, K.R., Van Domelen, D.R., & Patel, K.V. (2014). Association of chronic widespread pain with objectively measured physical activity in adults: findings from the National Health and Nutrition Examination Survey. The Journal of Pain, 15(5): 507-15. doi: 10.1016/j.jpain.2014.01.489.

Van Domelen, D.R., Caserotti, P., Brychta, R.J., Harris, T.B., Patel, K.V., Chen, K.Y., Arnardottir, N.Y., Eirikdottir, G., Launer, L.J., Gudnason, V., Sveinsson, T., Johannsson, E., & Koster, A. (2014). Is there a sex difference in accelerometer counts during walking in older adults? Journal of Physical Activity & Health, 11(3) 626-637. doi: 10.1123/jpah.2012-0050.

Arnardottir, N.Y., Koster, A., Van Domelen, D.R., Brychta, R.J., Caserotti, P., Eiriksdottir, G., Sverrisdottir, J.E., Launer, L.J., Gudnason, V., Johannsson, E., Harris, T.B., & Sveinsson, T. (2013). Objective measurements of daily physical activity patterns and sedentary behaviour in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study. Age & Ageing, 42(2) 222-229. doi: 10.1093/ageing/afs160.

Koster, A., Caserotti, P., Patel, K.V., Matthews, C.E., Berrigan, D., Van Domelen, D.R., Brychta, R.J., Chen, K.Y., & Harris, T.B. (2012). Association of sedentary time with mortality independent of moderate to vigorous physical activity. PLOS ONE, 7(6): e37696. doi: 10.1371/journal.pone.0037696.

Van Domelen, D.R., Koster, A., Caserotti, P., Brychta, R.J., Chen, K.Y., McClain, J.J., Troiano, R.P., Berrigan, D., & Harris, T. B. (2011). Employment and physical activity in the US. American Journal of Preventive Medicine, 41(2), 136-145. doi: 10.1016/j.amepre.2011.03.019.

Van Domelen, D.R., Koster, A., & Harris, T.B. (2011). Accelerometer nonwear algorithms: optimizing parameters for both wear states. Medicine & Science in Sports & Exercise, 43(5), 932. Letter to editor. doi: 10.1249/MSS.0b013e318212b002.

Van Domelen, D.R., Ausprung, L., Rogness, O., & Karpinski, N. (2009). Designing a self-adjusting ankle brace. Biomedical Sciences Instrumentation, 45, 328-333. Abstract.


Research Experience


Aug. 2018-July 2019: Johns Hopkins University, Baltimore, MD

Aug. 2012-Aug. 2018: Emory University, Atlanta, GA

Oct. 2009-July 2012: National Institute on Aging, Bethesda, MD

Summer 2008: National Cancer Institute, Bethesda, MD

Summer 2007: University of California, Irvine, Irvine, CA


R Packages on GitHub


accelerometry

dvmisc

nhanesaccel

nhanesdata

pooling

stocks

tab


Web Applications


Process NHANES accelerometer data