Dane R. Van Domelen

Website | GitHub page

Address:
85 Wells Ave., 2nd floor
Newton, MA 02459

Contact:
vandomed@gmail.com

(Last updated Aug. 26, 2022)

Education

2018: PhD in Biostatistics, Emory University

2016: MS in Biostatistics, Emory University

2009: BS in Biomedical Engineering, Milwaukee School of Engineering

Work

Karyopharm Therapeutics Inc., Newton, MA

July 2022-Present: Principal Biostatistician

Lead biostatistician on multiple myeloma trials.
Protocol/SAP, trial design (including adaptive), simulations in EAST/R, ADaM/TLF oversight.
Experience on regulatory submissions and communications.

July 2020-June 2022: Senior Biostatistician

July 2019-June 2020: Biostatistician

Johns Hopkins Bloomberg School of Public Health, Baltimore, MD

Aug. 2018-June 2019: Postdoctoral Fellow in Biostatistics

Measurement error methods for wearable device data.
Parameter estimation for frailty measures in older adults.

Awards

2018-2019: Epidemiology and Biostatistics of Aging Training Grant (NIA-T32)

Funding for 1-year postdoc at Johns Hopkins University.

2013-2018: National Science Foundation Graduate Research Fellowship

Proposal entitled “Likelihood-based methods for using internal and external validation data to correct for measurement error.”
$34,000 stipend and $12,000 cost-of-education allowance annually for three years.

2012-2017: George W. Woodruff Fellowship

Most prestigious entering student fellowship in the Laney Graduate School at Emory University.
Awarded annually to 15 entering students who show exceptional promise as future leaders in their field.

Publications

Methodological

Van Domelen, D.R. & Lyles, R.H. (2020). Formulas and web app for designing a pooling study to compare group means. Epidemiology, 31(1): 98-102. doi: 10.1097/EDE.0000000000001104.

Van Domelen, D.R. & Bandeen-Roche, K. (2019). A note on proposed estimation procedures for claims-based frailty indexes. American Journal of Epidemiology, 189(5): 369-371. doi: 10.1093/aje/kwz247.

Van Domelen, D.R., Mitchell, E.M., Perkins, N.J., Schisterman, E.F., Manatunga, A.K., Huang, Y., & Lyles, R.H. (2019). Gamma models for estimating the odds ratio for a skewed biomarker measured in pools and subject to errors. Biostatistics. doi: 10.1093/biostatistics/kxz028.

Van Domelen, D.R. & Lyles, R.H. (2019). A look at propensity score calibration’s unique identifiability. American Journal of Epidemiology, 188 (7): 1397–1399. doi: 10.1093/aje/kwz072.

Van Domelen, D.R., Mitchell, E.M., Perkins, N.J., Schisterman, E.F., Manatunga, A.K., Huang, Y., & Lyles, R.H. (2018). Logistic regression with a continuous exposure measured in pools and subject to errors. Statistics in Medicine, 37(27): 4007-4021. doi: 10.1002/sim.7891.

Lyles, R.H., Van Domelen, D.R., Mitchell, E.M., & Schisterman, E.F. (2015). A discriminant function approach to adjust for processing and measurement error when a biomarker is assayed in pooled samples. International Journal of Environmental Research and Public Health, 12(11): 14723-14740. doi: 10.3390/ijerph121114723.

Applied

Gounder, M.M., Razak, A.A., Somaiah, N., Chawla, S., Martin-Broto, J., Grignani, G., Schuetze, S.M., Vincenzi, B., Wagner, A.J., Chmielowski, B., Jones, R.L., Riedel, R.F., Stacchiotti, S., Loggers, E.T., Ganjoo, K.N., Le Cesne, A., Italiano, A., Garcia Del Muro, X., Burgess, M., Piperno-Neumann, S., Ryan, C., Mulcahy, M.F., Forscher, C., Penel, N., Okuno, S., Elias, A., Hartner, L., Philip, T., Alcindor, T., Kasper, B., Reichardt, P., Lapeire, L., Blay, J.Y., Chevreau, C., Valverde Morales, C.M., Schwartz, G.K., Chen, J.L., Deshpande, H., Davis, E.J., Nicholas, G., Gröschel, S., Hatcher, H., Duffaud, F., Herráez, A.C., Beveridge, R.D., Badalamenti, G., Eriksson, M., Meyer, C., von Mehren, M., Van Tine, B.A., Götze, K., Mazzeo, F., Yakobson, A., Zick, A., Lee, A., Gonzalez, A.E., Napolitano, A., Dickson, M.A., Michel, D., Meng, C., Li, L., Liu, J., Ben-Shahar, O., Van Domelen, D.R., Walker, C.J., Chang, H., Landesman, Y., Shah, J.J., Shacham, S., Kauffman, M.G., Attia, & S. Selinexor in advanced, metastatic dedifferentiated liposarcoma: a multinational, randomized, double-blind, placebo-controlled trial. Journal of Clinical Oncology, 40(22): 2479-2490. doi: 10.1200/JCO.21.01829.

Gasparetto, C., Schiller, G.J., Tuchman, S.A., Callander, N.S., Baljevic, M., Lentzsch, S., Rossi, A.C., Kotb, R., White, D., Bahlis, N.J., Chen, C.I., Sutherland, H.J., Madan, S., LeBlanc, R., Sebag, M., Venner, C.P., Bensinger, W.I., Biran, N., Ammu, S., Ben-Shahar, O., DeCastro, A., Van Domelen, D., Zhou, T., Zhang, C., Bentur, O.S., Shah, J., Shacham, S., Kauffman, M., & Lipe, B. (2021). Once weekly selinexor, carfilzomib and dexamethasone in carfilzomib non-refractory multiple myeloma patients. British Journal of Cancer. doi: 10.1038/s41416-021-01608-2.

Gasparetto, C., Lentzsch, S., Schiller, G., Callander, N., Tuchman, S., Chen, C., White, D., Kotb, R., Sutherland, H., Sebag, M., Baljevic, M., Bensinger, W., LeBlanc, R., Venner, C., Bahlis, N., Rossi, A., Biran, N., Sheehan, H., Saint-Martin, J.R., Van Domelen, D., Kai, K., Shah, J., Shacham, S., Kauffman, M. & Lipe, B. (2021). Selinexor, daratumumab, and dexamethasone in patients with relapsed or refractory multiple myeloma. eJHaem, 2(1): 56-65. doi: 10.1002/jha2.122.

Steeves, J.A., Shiroma, E.J., Conger, S.A., Van Domelen, D.R., & Harris, T.B. (2019). Physical activity patterns and multimorbidity burden of older adults with different levels of functional status. Disability and Health Journal, 12(3): 495-502. doi: 10.1016/j.dhjo.2019.02.005.

van der Berg, J.D., Stehouwer, C.D.A., Bosma, H., Caserotti, P., Eiriksdottir, G., Arnardottir, N.Y., Van Domelen, D.R., Brychta, R.J., Chen, K.Y., Sveinsson, T., Johannsson, E., Launer, L.J., Gudnason, V., Jonsson, P.V., Harris, T.B., & Koster, A. (2019). Dynamic sitting: Measurement and associations with metabolic health. Journal of Sports Sciences, 36(17): 1-9. doi: 10.1080/02640414.2019.1592800.

Steeves, J.A., Tudor-Locke, C., Murphy R.A., King G.A., Fitzhugh, E.C., Bassett, D.R., Van Domelen, D.R., Schuna, J.M., & Harris, T.B. (2018). Daily physical activity by occupational classification in US adults: NHANES 2005-2006. Journal of Physical Activity and Health, 15(12): 900-911. doi: 10.1123/jpah.2017-0465.

Van Domelen, D.R. (2018). Frequent activity and minimal sedentary time throughout the day: an impractical goal with unproven benefits. Letter to editor. Journal of Physiology, 596(8): 1527. doi: 10.1113/JP275108.

Arnardottir, N.Y., Oskarsdottir, N.D., Brychta, R.J., Koster, A., Van Domelen, D.R., Caserotti, P., Eiriksdottir, G., Sverrisdottir, J.E., Johannsson, E., Launer, L.J., Gudnason, V., Harris, T.B., Chen, K.Y., & Svensson, T. (2017). Comparison of summer and winter objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility Reykjavik Study. International Journal of Environmental Research and Public Health, 14(10): 1268. doi: 10.3390/ijerph14101268.

Matthews, C.E., Keadle, S.K., Troiano, R.P., Kahle, L., Koster, A., Brychta, R.J., Van Domelen, D.R., Caserotti, P., Chen, K.Y., Harris, T.B., & Berrigan, D. (2016). Accelerometer-measured dose-response for physical activity, sedentary time, and mortality in US adults. American Journal of Clinical Nutrition, 104(5): 1424-1432. doi: 10.3945/ajcn.116.135129.

Kwak, L., Berrigan, D., Van Domelen, D.R., Sjostrom, M., & Hagstromer, M. (2016). Examining differences in physical activity levels by employment status and/or job activity level: Gender-specific comparisons between the United States and Sweden. Journal of Science and Medicine in Sport, 19(6): 482-7. doi: 10.1016/j.jsams.2015.05.008.

Arnardottir, N.Y., Koster, A., Van Domelen, D.R., Brychta, R.J., Caserotti, P., Eiriksdottir, G., Sverrisdottir, J.E., Sigurdsson, S., Johannsson, E., Chen, K.Y., Gudnason, V., Harris, T.B., Launer, L.J., & Sveinsson, T. (2015). Association of change in brain structure to objectively measured physical activity and sedentary behavior in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study. Behavioural Brain Research, 296: 118-24. doi: 10.1016/j.bbr.2015.09.005.

Van Domelen, D.R. (2015). Part-time work and physical activity in American high school students. Journal of Occupational and Environmental Medicine, 57(8): 904-9. doi: 10.1097/JOM.0000000000000497.

Steeves, J.A., Murphy, R.A., Crainiceanu, C.M., Zipunnikov, V., Van Domelen, D.R., & Harris, T.B. (2015). Daily patterns of physical activity by type 2 diabetes definition: Comparing diabetes, prediabetes, and participants with normal glucose levels in NHANES 2003-2006. Preventive Medicine Reports, 2: 152-7. doi: 10.1016/j.pmedr.2015.02.007.

Martin, K.R., Koster, A., Murphy, R.A., Van Domelen, D.R., Hung, M., Brychta, R.J., Chen, K.Y., & Harris, T.B. (2015). Changes in daily activity patterns with age among US men and women: NHANES 2003-04 and 2005-06. Journal of the American Geriatrics Society, 62(7): 1263-71. doi: 10.1111/jgs.12893.

Van Domelen, D.R. & Pittard, W.S. (2014). Flexible R functions for processing accelerometer data, with emphasis on NHANES 2003-2006. The R Journal, 6(2): 52-62. Article.

Hunt, M.O., Weissfeld, L., Boudreau, R.M., Aizenstein, H., Newman, A.B., Simonsick, E.M., Van Domelen, D.R., Thomas, F., Yaffe, K., & Rosana, C. (2014). A variant of sparse partial least squares for variable selection and data exploration. Frontiers in Neuroinformatics, 8(18). doi: 10.3389/fninf.2014.00018.

Dansie, E.J., Turk, D.C., Martin, K.R., Van Domelen, D.R., & Patel, K.V. (2014). Association of chronic widespread pain with objectively measured physical activity in adults: findings from the National Health and Nutrition Examination Survey. The Journal of Pain, 15(5): 507-15. doi: 10.1016/j.jpain.2014.01.489.

Van Domelen, D.R., Caserotti, P., Brychta, R.J., Harris, T.B., Patel, K.V., Chen, K.Y., Arnardottir, N.Y., Eirikdottir, G., Launer, L.J., Gudnason, V., Sveinsson, T., Johannsson, E., & Koster, A. (2014). Is there a sex difference in accelerometer counts during walking in older adults? Journal of Physical Activity & Health, 11(3) 626-637. doi: 10.1123/jpah.2012-0050.

Arnardottir, N.Y., Koster, A., Van Domelen, D.R., Brychta, R.J., Caserotti, P., Eiriksdottir, G., Sverrisdottir, J.E., Launer, L.J., Gudnason, V., Johannsson, E., Harris, T.B., & Sveinsson, T. (2013). Objective measurements of daily physical activity patterns and sedentary behaviour in older adults: Age, Gene/Environment Susceptibility-Reykjavik Study. Age & Ageing, 42(2) 222-229. doi: 10.1093/ageing/afs160.

Koster, A., Caserotti, P., Patel, K.V., Matthews, C.E., Berrigan, D., Van Domelen, D.R., Brychta, R.J., Chen, K.Y., & Harris, T.B. (2012). Association of sedentary time with mortality independent of moderate to vigorous physical activity. PLOS ONE, 7(6): e37696. doi: 10.1371/journal.pone.0037696.

Van Domelen, D.R., Koster, A., Caserotti, P., Brychta, R.J., Chen, K.Y., McClain, J.J., Troiano, R.P., Berrigan, D., & Harris, T. B. (2011). Employment and physical activity in the US. American Journal of Preventive Medicine, 41(2), 136-145. doi: 10.1016/j.amepre.2011.03.019.

Van Domelen, D.R., Koster, A., & Harris, T.B. (2011). Accelerometer nonwear algorithms: optimizing parameters for both wear states. Medicine & Science in Sports & Exercise, 43(5), 932. Letter to editor. doi: 10.1249/MSS.0b013e318212b002.

Van Domelen, D.R., Ausprung, L., Rogness, O., & Karpinski, N. (2009). Designing a self-adjusting ankle brace. Biomedical Sciences Instrumentation, 45, 328-333. Abstract.

Research Experience

Aug. 2018-July 2019: Johns Hopkins University, Baltimore, MD

Postdoctoral fellow in the Department of Biostatistics.
Worked on wearable monitors (e.g. accelerometers) and epidemiology of aging.

Aug. 2012-Aug. 2018: Emory University, Atlanta, GA

Dissertation research on structural methods for measurement error and unmeasured confounding, and methods for analyzing pooled biomarker data.

Oct. 2009-July 2012: National Institute on Aging, Bethesda, MD

Research fellow in the Laboratory of Epidemiology and Population Science, mentored by Tamara B. Harris.
MATLAB programming and statistical analysis in SPSS, SAS, Stata, and R.

Summer 2008: National Cancer Institute, Bethesda, MD

Biomedical Engineering Summer Internship Program.
Processed data for visualizing HIV glycoproteins using cryo-electron tomography.

Summer 2007: University of California, Irvine, Irvine, CA

Worked with Marc Madou on Bio-MEMS Laboratory’s “lab on a CD” project.
Designed, fabricated, and tested disc that performed solid phase extraction.

R Packages on GitHub

accelerometry

Functions for processing accelerometer data.
C++ code used internally for speed.

dvmisc

Convenience functions, moving window statistics, and graphics.
E.g. run and summarize simulations, plot histogram with fitted densities and AICs.

nhanesaccel

Process accelerometer data from NHANES 2003-2006.
Highly customizable to accommodate various methods.
Roughly 90x faster than National Cancer Institute’s SAS programs.

nhanesdata

Data from continuous NHANES (years 1999-2016).
Makes it easy to load data into R.

pooling

Fit poolwise regression models.
Maximum likelihood methods accounting for assay measurement errors.
Also has tools for designing pooling studies (e.g. optimal pool size, cost savings).

stocks

Stock market analysis.
Calculate metrics, visualize 2- and 3-fund portfolios, etc.

tab

Create summary tables for statistical reports.
Contingency tables, comparison of means/medians, GLMs, GEEs, Cox PH.

Web Applications

Process NHANES accelerometer data

Crowdsourced livestreams for city and neighborhood security

Conferences

Presented

Van Domelen, D.R. & Zipunnikov, V. (2019; poster). Wearable devices are objective but imperfect–towards correcting for two sources of error. ENAR 2019 Spring Meeting. Philadelphia, PA, March 24-27, 2019. Program.

Van Domelen, D.R., Mitchell, E.M., Schisterman, E.F., Perkins, N.J., & Lyles, R.H. (2018; SPEED talk/e-poster). Logistic regression with a right-skewed exposure variable measured in pools and subject to errors. 2018 Joint Statistical Meeting. Vancouver, BC, July 28-Aug. 2, 2018. Abstract.

Van Domelen, D.R. (2017; invited talk). Accelerometry: A better method, and a new set of problems. 2017 Duke Industry Statistics Symposium. Durham, NC, Sep. 6-8, 2017. Slides.

Van Domelen, D.R., Mitchell E.M., Manatunga A.K., Lyles R.H., & Schisterman, E.F. (2017; talk). Maximum likelihood-based regression with a continuous exposure variable assessed in pools and subject to measurement and processing errors. 2017 Joint Statistical Meeting. Baltimore, MD, July 29-Aug. 3, 2017. Abstract.

Van Domelen, D.R., Lyles, R.H., Mitchell, E.M., & Schisterman, E.F. (2015; poster). A comparison of methods to address unmeasured confounding when internal or external validation data are available. 2015 Joint Statistical Meeting. Seattle, WA, Aug. 8-13, 2015. Abstract.

Van Domelen, D.R., Koster, A., Caserotti, P., Brychta, R.J., Chen, K.Y., McClain J.J., Troiano, R.P., Berrigan, D., & Harris, T.B. (2010; poster). Employment and daily physical activity in America. ACSM Conference on Integrative Physiology of Exercise. Miami Beach, FL, Sep. 22-25, 2010.

Van Domelen, D.R. (2008; talk). Molecular structure of the trimeric HIV-1 envelope glycoprotein. Biomedical Engineering Summer Internship Program Symposium. Bethesda, MD, Aug. 8, 2008.

Van Domelen, D.R. (2007; talk). Centrifugal (CD) microfluidic solid-phase extraction. Integrated Micro/nano Summer Undergraduate Research Experience Symposium. Irvine, CA, Aug. 29, 2007. Slides.

Contributed

Jagannath, S., Facon, T., Badros, A., Levy, M., Moreau, P., Delimpasi, S., Simonova, M., Spicka, I., Kriachok, I., Gavriatopoulou, M., Pylypenko, H., Auner, H.W., Leleu, X., Doronin, V., Usenko, G., Hajek, R., Benjamin, R., Dolai, T.K., Sinha, D.K., Venner, C.P., Garg, M., Mesa, M.G., Jurczyszyn, A., Robak, T., Galli, M., Wallington-Beddoe, C.T., Radinoff, A., Salogub, G., Stevens, D., Basu, S., Liberati, A.M., Quach, H., Goranova Marinova, V.S., Bila, J.S., Katodritou, E., DeCastro, A., Chai, Y., Van Domelen, D.R., Mishal, M., Bentur, O.S., Shah, J., Shacham, S., Kauffman, M.G., Grosicki, S., & Richardson, P.G. (2021). Clinical outcomes in patients (pts) with dose reduction of selinexor in combination with bortezomib, and dexamethasone (XVd) in previously treated multiple myeloma from the BOSTON study. 63rd ASH Annual Meeting and Exposition. Atlanta, GA, Dec. 11-14, 2021. Abstract.

White, D.J., Chen, C.I., Baljevic, M., Tuchman, S.A., Bahlis, N.J., Schiller, G.J., Lipe, B., Kotb, R., Sutherland, H.J., Bensinger, W.I., Madan, S., Sebag, M., Lentzsch, S., Callander, N.S., Biran, N., Venner, C.P., Leblanc, R., Monge, J., Chubar, E., Tadmor, T., Lavi, N., Leiba, M., DeCastro, A., Van Domelen, D.R., Zhang, C., Mishal, M., Bentur, O.S., Shah, J.J., Shacham, S., Kauffman, M.G., & Gasparetto, C.J. (2021). Once weekly oral selinexor, pomalidomide, and dexamethasone in relapsed refractory multiple myeloma. 63rd ASH Annual Meeting and Exposition. Atlanta, GA, Dec. 11-14, 2021. Abstract.

Bahlis, N.J., Richard, S., White, D.J., Grosicki, S., Chen, C.I., Delimpasi, S., Sutherland, H.J., Maslyak, Z., Sebag, M., Gavriatopoulou, M., Lentzsch, S., Chari, A., Simonova, M., Spicka, I., Kriachok, I., Dimopoulos, M.A., Pylypenko, H., Auner, H.W., Leleu, X., Usenko, G., Hajek, R., Benjamin, R., Dolai, T.K., Sinha, D.K., Venner, C.P., Garg, M., Stevens, D., Quach, H., Jagannath, S., Moreau, P., Levy, M., Badros, A., Anderson, L.D., Facon, T., Mateos, M.V., Cavo, M., DeCastro, A., Chai, Y., Van Domelen, D.R., Mishal, M., Bentur, O.S., Shah, J., Shacham, S., Kauffman, M.G., & Richardson, P.G. (2021). Effects of cytogenetic risk on outcomes in multiple myeloma treated with selinexor, bortezomib, and dexamethasone (XVd). 63rd ASH Annual Meeting and Exposition. Atlanta, GA, Dec. 11-14, 2021. Abstract.

Sudalagunta, P.R., Renatino-Canevarolo, R., Meads, M.B., Coelho Siqueira Silva, M.D., Cubitt, C., De Avila, G., Alugubelli, R.R., Logothetis, C., Zhang, Q., Hampton, O., DeCastro, A., Van Domelen, D.R., Chai, Y., Walker, C.J., Silva, A.S., Landesman, Y., Baz, R., & Shain, K.H. (2021). Rationale for selinexor treatment in daratumumab-refractory MM patients identified by paired ex vivo drug sensitivity and RNA-seq. 63rd ASH Annual Meeting and Exposition. Atlanta, GA, Dec. 11-14, 2021. Abstract.

Lentzsch, S., Lipe, B., Tuchman, S., Bahlis, N.J., Bensinger, W.I., Sebag, M., Sutherland, H.J., Monge, J., Gasparetto, C., Baljevic, M., Callander, N.S., Venner, C.P., White, D.J., Kotb, R., Chen, C.I., Schiller, G.J., Madan, S., Leblanc, R., DeCastro, A., Bentur, O.S., Shah, J.J., Van Domelen, D.R., Kauffman, M.G., Shacham, S., & Biran, N. (2021). Efficacy and safety of selinexor-containing regimens in patients with multiple myeloma previously treated with anti-CD38 monoclonal antibodies. 63rd ASH Annual Meeting and Exposition. Atlanta, GA, Dec. 11-14, 2021. Abstract.

Baljevic, M., Gasparetto, C., Schiller, G., Tuchman, S., Callander, N.S., Lentzsch, S., Monge, J., Kotb, R., Bahlis, N.J., White, D., Chen, C.I., Sutherland, H.J., Madan, S., Leblanc, R., Sebag, M., Venner, C.P., Bensinger, W.I., Biran, N., DeCastro, A.,Van Domelen, D., Bentur, O.S., Zhang, C., Shah, J.J., Shacham, S., Kauffman, M.G., & Lipe, B. (2021). Selinexor-based regimens in patients with multiple myeloma after prior anti-B-cell maturation antigen treatment. 63rd ASH Annual Meeting and Exposition. Atlanta, GA, Dec. 11-14, 2021. Abstract.

White, D., Chen, C., Baljevic, M., Tuchman, S., Bahlis, N., Schiller, G., Lipe, B., Kotb, R., Sutherland, H., Madan, S., Sebag, M., Lentzsch, S., Callander, N.S., Biran, N., Venner, C., LeBlanc, R., Rossi, A., Van Domelen, D., Zhou, T., Shah, J., Kauffman, M., Shacham, S., & Gasparetto, C. (2021). Oral selinexor, pomalidomide, and dexamethasone (XPd) at recommended phase 2 dose in relapsed/refractory multiple myeloma (MM). 26th Congress of the EHA. Virtual, June 9-17, 2021. Abstract.

Gasparetto, C., Schiller, G., Tuchman, S., Callander, N., Baljevic, M., Lentzsch, S., Rossi, A., Kotb, R., White, D., Bahlis, N., Chen, C., Sutherland, H., Madan, S., LeBlanc, R., Sebag, M., Venner, C., Biran, N., Van Domelen, D., Zhou, T., Shah, J., Kauffman, M., Shacham, S., & Lipe, B. (2021). Once weekly selinexor, carfilzomib, and dexamethasone (XKd) in carfilzomib nonrefractory multiple myeloma (MM) patients. 26th Congress of the EHA. Virtual, June 9-17, 2021. Abstract.

Gasparetto, C., Schiller, G.J., Tuchman, S.A., Callander, N.S., Baljevic, M., Lentzsch, S., Rossi, A.C., Kotb, R., White, D., Bahlis, N.J., Chen, C.I., Sutherland, H.J., Madan, S., LeBlanc, R., Sebag, M., Venner, C.P., Bensinger, W.I., Biran, N., Van Domelen, D., & Lipe, B. (2021). Once weekly selinexor, carfilzomib, and dexamethasone (XKd) in heavily pretreated multiple myeloma (MM). 2021 ASCO Annual Meeting. Virtual, June 4-8, 2021. Presentation.

Chen, C.I., Bahlis, N., Gasparetto, C., Tuchman, S.A., Lipe, B., Baljevic, M., Kotb, R., Sutherland, H.J., Bensinger, W.I., Sebag, M., LeBlanc, R., Venner, C.P., Schiller, G.J., Lentzsch, S., Callander, N.S., Rossi, A.C., Sheehan, H., Van Domelen, D., Kazuharu, K., Wang, H., Shah, J., Shacham, S., Kauffman, M.G., & White, D.J. (2020). Selinexor in combination with pomalidomide and dexamethasone (SPd) for treatment of patients with relapsed refractory multiple myeloma (RRMM). 62nd ASH Annual Meeting and Exposition. Virtual, Dec. 5-8, 2020. Abstract.

Gasparetto, C., Lipe, B., Tuchman, S.A., Callander, N.S., Lentzsch, S., Baljevic, M., Rossi, A.C., Bahlis, N., White, D.J., Chen, C.I., Sutherland, H.J., Kotb, R., LeBlanc, R., Sebag, M., Venner, C.P., Bensinger, W.I., Sheehan, H., Van Domelen, D., Kazuharu, K., & Schiller, G.J. (2020). Selinexor in combination with carfilzomib and dexamethasone, all once weekly (SKd), for patients with relapsed/refractory multiple myeloma. 62nd ASH Annual Meeting and Exposition. Virtual, Dec. 5-8, 2020. Abstract.

White, D.J., LeBlanc, R., Baljevic, M., Bahlis, N., Lentzsch, S., Venner, C.P., Gasparetto, C., Chen, C.I., Lipe, B., Tuchman, S.A., Sutherland, H.J., Kotb, R., Sebag, M., Callander, N.S., Bensinger, W.I., Rossi, A.C., Sheehan, H., Van Domelen, D., Zhou, T., Kazuharu, K., Shah, J., Shacham, S., Kauffman, M.G., & Schiller, G.J. (2020). Selinexor, lenalidomide and dexamethasone (SRd) for patients with relapsed/refractory and newly diagnosed multiple myeloma. 62nd ASH Annual Meeting and Exposition. Virtual, Dec. 5-8, 2020. Abstract.

Artstein, Y., Walker, C., Yang, F., Van Domelen, D., Borochov, D., Mercier, I., Shah, J., Schacham, S., Landesman, Y., Tang, S., & Shacham, E. Machine learning models predict selinexor tolerability and efficacy. ESMO Virtual Congress 2020. Virtual, Sep. 19-21, 2020. Abstract.

Steeves, J., Tudor-Locke, C., Murphy, R.A., King, G.A., Bassett, D.R., Van Domelen, D.R., Schuna, J.M., & Harris, T.B. (2018). Objectively measured physical activity across occupations based on the NHANES. Gerontological Society of America 70th Annual Scientific Meeting. Boston, MA, Nov. 14-18, 2018. Abstract.

Harris, T.B., Chen, K.Y., Brychta, R.J., Caserotti, P., Shiroma, E.J., Van Domelen, D.R., Launer, L.J., Gudnason, V., Arnardottir, N.Y., Sveinsson, T., Johannsson, E., Eiriksdottir, G., & Koster, A. (2016). Daily physical activity and mortality risk in the very old: Age, Gene/Environment-Reykjavik Study. ACSM Annual Meeting. Boston, MA, May 31-June 4, 2016. Abstract.

Patel, K.V., Morgan, J., Turk, D., & Van Domelen, D.R. (2016). Self-reported and objectively monitored physical activity in a nationally-representative sample of adults with and without chronic pain. American Pain Society Annual Scientific Meeting. Austin, TX, May 11-14. Abstract.

Gillespie, S., McCracken, C., Van Domelen, D.R., & Leong, T. (2014). Multi-center clinical trials reporting with R. useR! The R User Conference 2014. Los Angeles, CA, June 30-July 3, 2014. Abstract.

Koster, A., Van Domelen, D.R., Caserotti, P., Brychta, R.J., Chen, K.Y., Arnardottir, N.Y., Eiriksdottir, G., Sveinsson, B., Johannsson, E., Gudnason, V., Launer, L.J., & Harris, T.B. (2013). The use of triaxial accelerometry data to define nonwear time. 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement. Amherst, MA, June 17-19, 2013. Abstract.

Martin, K.R., Koster, A., Murphy, R.A., Van Domelen, D.R., Hung, M., Brychta, R., Chen, K.Y., & Harris, T.B. (2013). Changes in daily activity patterns with advancing age among US men and women. 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement. Amherst, MA, June 17-19, 2013. Abstract.

Tom, S. E., Martin, K.R., Van Domelen, D.R., & Patel, K.V. (2013). Associations between daytime sleepiness and sleep duration with accelerometer-measured physical activity in NHANES 2005-2006. 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement. Amherst, MA, June 17-19, 2013. Abstract.

Harris, T.B., Caserotti, P., Chen, K., Glynn, N., Brychta, R., Matthews, C., Maia, B.L., Van Domelen, D.R., Shen, H.M., Hung, M., & Koster, A. (2013). Aging research evaluating accelerometry: methodologic comparisons of accelerometry performance in the very old. 3rd International Conference on Ambulatory Monitoring of Physical Activity and Movement. Amherst, MA, June 17-19, 2013. Abstract.

Pantell, M.S., Patel, K.V., Harris, T.B., & Van Domelen, D.R. (2012). Socioeconomic status, race/ethnicity, and physical activity as measured by accelerometry: Which direction does the social gradient go and for whom? 140th APHA Annual Meeting and Exposition. San Francisco, CA, Oct. 27-31, 2012. Abstract.

Patel, K.V., Koster, A., Caserotti, P., Van Domelen, D.R., & Harris, T.B. (2011). Association of free-living physical activity and sedentary behavior with the red cell distribution width. Gerontological Society of America 64th Annual Scientific Meeting. Boston, MA, Nov. 18-22, 2011.

Reviewer

Teaching Activities

2013-2018: Teaching assistant, Emory University, Atlanta, GA

BIOS 545: Introduction to R programming (8 semesters).
BIOS 506: Biostatistical Methods I (1 semester).
Help students during lab, hold weekly office hour, grade homework and exams.

2007-2008: TRIO tutor, Milwaukee School of Engineering, Milwaukee, WI

Program provides tutoring for students from disadvantaged backgrounds.
Tutored chemistry, statistics, and engineering courses (150+ hours).

Volunteerism

2016-2018: Charity poker, Atlanta, GA

Hosted $10 buy-in poker tournaments. Winner chose charity to donate pot to.
Raised $1,075 for charities including Guide Dog Foundation, Partners in Health, and World Food Programme.

2016-8: Tutor for charity, Atlanta, GA

Tutored Emory students in biostatistics.
Gave 100% of earnings to Share the Meal mobile app.
Raised over $1,800.

2014-2018: Big Brothers Big Sisters, Atlanta, GA

Weekly volunteer and part of “Mentoring Towards College” program.
Homework, pizza, and Nerf wars.

2009: Bike & Build

Rode bicycle from Charleston, SC, to Santa Cruz, CA, in group of 32 young adults.
Raised $4,000 for affordable housing; helped build homes throughout U.S.

2007-2008: Big Brothers Big Sisters, Milwaukee, WI

Weekly volunteer with 13-year old boy.
Homework, sports, museums, etc.

Extracurriculars

2012-2017: Captain of Emory biostatistics intramural sports teams, Atlanta, GA

Organized teams for flag football (6 seasons) and volleyball (3 seasons).
Rarely won but played with heart.

2006-2009: President of racquet-sports club at Milwaukee School of Engineering, Milwaukee, WI

Organized tournaments for table tennis, racquetball, and foosball.

2008: Club lacrosse at Milwaukee School of Engineering, Milwaukee, WI

Played midfielder for one season.

2005-2006: Varsity golf at Milwaukee School of Engineering, Milwaukee, WI

Played for two seasons.